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It is well accepted that having a 500 calorie deficit per day allows humans to lose 1 pound of fat in 1 week.
Caloric deficit is either less food or more physical activity (or both).
You would need to have a 12,500 calorie deficit per day to lose 50 pounds in 2 weeks.
If you currently eat way too many calories per day, such as those that weigh 300–400 kg, it is possible.
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